Missense mutations
(click to a mutation to access 3D structures)
Residue:
67
95
142
212
339
371
373
375
417
440
446
477
478
484
493
496
498
501
505
547
614
655
679
681
764
796
856
954
969
981
Wildtype:
A
T
G
L
G
S
S
S
K
N
G
S
T
E
Q
G
Q
N
Y
T
D
H
N
P
N
D
N
Q
N
L
Omicron:
V
I
D
I
D
L
P
F
N
K
S
N
K
A
K
S
R
Y
H
K
G
Y
K
H
K
Y
K
H
K
F
Structures:
-
4
33
-
3
35
1
1
27
4
1
3
55
1
1
1
3
67
3
2
109
12
-
-
-
20
2
-
1
-
Missing in
all structures
Missing in
this structure
R214_D215insEPE
V143_Y145del
H69_V70del
Insertions & deletions
aquaria.app/SARS-CoV-2/S/7sbs
?
zenodo
.
5519546
.
omicron
#
(-10,-262,-2)
Y41
N501Y
ACE2
Q498R
aquaria.app/SARS-CoV-2/S/7bh9/E?
N501Y
&
Q498R
#E502&(-26,-73,111)&1069%
Two mutations in spike glycoprotein (Q498R and N501Y) appear to drive omicron’s heightened transmissibility. These mutations occur at the
end of the spike trimer (right), in the region that binds to residue Y41 of ACE2 (left). In total, omicron has 33 mutations (below), of which
seven currently have no structural data (bottom of page, last row). Generated using
Aquaria.App
(Kaur et al., 2021
).
The mutations driving omicron transmissibility